Enhancement of Liver Microsome Epoxide Hydratase Activity in Rodents by Treatment with 2(3)-tert-Butyl-4-hydroxyanisole1
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چکیده
Administrationof the antioxidant 2(3)-tert-butyl-4-hy droxyanisole(BHA)in the diet causeda markedincrease in the specific activity of epoxide hydratase (EC 4.2.1.63) in hepatic microsomesof CD-i mice. The increases in epoxide hydratase activities produced by BHA were far greater (11-fold)than were those producedby the admin istrationof well-knownenzymeinducerssuchas 3-meth ylcholanthrene,phenobarbital,and Arocbor1254 (2to 3fold). The near-maximal Increase in epoxide hydratase activitywas observedafter feedingof the BHAdiet for 3 days. When BHAwas administeredby gastricintubation, the bevelof increase was only 75% of that attained by feeding BHA in the diet. The increase in epoxide hydra tase activityproducedby BHAtreatmentof Sprague-Daw Icy ratswas notas pronounced(<3-fold)as that observed InCD-i mice.
منابع مشابه
Enhancement of liver microsome epoxide hydratase activity in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole.
Administration of the antioxidant 2(3)-tert-butyl-4-hydroxyanisole (BHA) in the diet caused a marked increase in the specific activity of epoxide hydratase (EC 4.2.1.63) in hepatic microsomes of CD-1 mice. The increases in epoxide hydratase activities produced by BHA were far greater (11-fold) than were those produced by the administration of well-known enzyme inducers such as 3-methylcholanthr...
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Butylated hydroxyanisole, a food additive, has been found to inhibit the neoplastic effects of a wide variety of chemical carcinogens. The commercially available preparations of butylated hydroxyanisole contain two isomers, 2-tert-butyl-4-hydroxyanisole (2-BHA) and 3-tert-butyl-4-hydroxyanisole (3-BHA). Both isomers induce increased activities of glutathione (GSH) S-transferase and epoxide hydr...
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